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Measuring treatment response in psychotic depression: the Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into account
Psychiatry Publications and Presentations
  • Soren Dinesen Ostergaard, Aalborg Psychiatric Hospital
  • Barnett S. Meyers, Weill Cornell Medical College
  • Alastair Flint, University of Toronto
  • Benoit H. Mulsant, University of Toronto
  • Ellen M. Whyte, University of Pittsburgh
  • Christine M. Ulbricht, University of Massachusetts Medical School
  • Per Bech, Psychiatric Center North Zealand
  • Anthony J. Rothschild, UMass Medical School
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type

BACKGROUND: There is no established psychometric instrument dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to investigate whether a new composite rating scale, the Psychotic Depression Assessment Scale (PDAS), covering both the psychotic and the depressive domains of PD, could detect differences in effect between two psychopharmacological treatment regimens.

METHODS: We reanalyzed the data from the Study of Pharmacotherapy of Psychotic Depression (STOP-PD), which compared the effect of Olanzapine+Sertraline (n=129) versus Olanzapine+Placebo (n=130). The response to the two regimens was compared using both a mixed effects model and effect size statistics on the total scores of three rating scales: the 17-item Hamilton Depression Rating Scale (HAM-D17), its 6-item melancholia subscale (HAM-D6), and the 11-item PDAS consisting of the HAM-D6 plus five items from the Brief Psychiatric Rating Scale covering psychotic symptoms.

RESULTS: According to both statistical approaches, the PDAS, the HAM-D17 and the HAM-D6 were all able to detect significant differences in treatment effect between Olanzapine+Sertraline and Olanzapine+Placebo (Olanzapine+Sertraline being superior). Notably, 45% of the trial participants were at least "probable psychotic" at their last assessment in the trial.

LIMITATIONS: The STOP-PD was not designed specifically to answer the research questions of the present study.

CONCLUSIONS: The Psychotic Depression Assessment Scale (PDAS) is a sensitive measure of treatment response in PD. The fact that 45% of the patients still experienced psychotic symptoms at their last trial assessment emphasizes the need to include items pertaining to psychotic symptoms in rating scales for PD.

DOI of Published Version
J Affect Disord. 2014 May;160:68-73. doi: 10.1016/j.jad.2013.12.020 Link to article on publisher's site
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Citation Information
Soren Dinesen Ostergaard, Barnett S. Meyers, Alastair Flint, Benoit H. Mulsant, et al.. "Measuring treatment response in psychotic depression: the Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into account" Vol. 160 (2014) ISSN: 0165-0327 (Linking)
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