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Article
The relationship between change in apathy and changes in cognition and functional outcomes in currently non-depressed SSRI-treated patients with major depressive disorder
Psychiatry Publications and Presentations
  • Anthony J. Rothschild, University of Massachusetts Medical School
  • Joel Raskin, Lilly Research Laboratories
  • Chia-Ning Wang, Eli Lilly China
  • Lauren B. Marangell, University of Texas Health Science Center School of Medicine
  • Maurizio Fava, Massachusetts General Hospital
UMMS Affiliation
Department of Psychiatry
Publication Date
1-1-2014
Document Type
Article
Subjects
Adolescent; Adult; Aged; Antidepressive Agents; *Apathy; *Cognition; Depressive Disorder, Major; Factor Analysis, Statistical; Female; Humans; Male; Middle Aged; *Motivation; Questionnaires; Serotonin Uptake Inhibitors; Treatment Outcome
Abstract

AIMS: Apathy in the context of treated major depressive disorder (MDD) is a frequently observed phenomenon in clinical practice. This study aimed to assess the validity of the Rothschild Scale for Antidepressant Tachyphylaxis(R) (RSAT) and the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (CPFQ) for measuring apathy, and to assess the relationship between apathy and possible contributing factors, in patients with MDD and residual apathy in the absence of depressed mood.

METHODS: The underlying structure and validity of the RSAT and CPFQ were assessed via factor analysis and correlation with the Apathy Evaluation Scale-Clinician rated version (AES-C) in 483 patients who had previously responded to treatment with a selective serotonin reuptake inhibitor. The relationship between apathy and contributing variables was investigated via structural equation modeling. Correlation and regression analyses were conducted to examine the relationship between the Sheehan Disability Scale (SDS) and the RSAT, CPFQ, and AES-C.

RESULTS: The RSAT and CPFQ were validated with the AES-C with respect to energy and motivation. The latent variable "Energy and Interest", based on the energy, motivation, and interest items (RSAT and CPFQ), was a major contributing factor to apathy. Improvements in function (SDS) were significantly correlated with, and predicted by, improvements in apathy and cognitive and physical functioning (assessed by the RSAT, CPFQ, and AES-C).

CONCLUSIONS: These analyses provide further information on apathy and its assessment in the context of treated MDD. A better understanding of apathy will aid further investigation of this phenomenon and, ultimately, determination of the most appropriate approach for its clinical management.

DOI of Published Version
10.1016/j.comppsych.2013.08.008
Source
Compr Psychiatry. 2014 Jan;55(1):1-10. doi: 10.1016/j.comppsych.2013.08.008. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
24268564
Citation Information
Anthony J. Rothschild, Joel Raskin, Chia-Ning Wang, Lauren B. Marangell, et al.. "The relationship between change in apathy and changes in cognition and functional outcomes in currently non-depressed SSRI-treated patients with major depressive disorder" Vol. 55 Iss. 1 (2014) ISSN: 0010-440X (Linking)
Available at: http://works.bepress.com/anthony_rothschild/127/