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Article
Assessing Rates and Predictors of Tachyphylaxis During the Prevention of Recurrent Episodes of Depression With Venlafaxine ER for Two Years (PREVENT) Study
Psychiatry Publications and Presentations
  • Anthony J. Rothschild, University of Massachusetts Medical School
  • Boadie W. Dunlop, Emory University
  • David L. Dunner
  • Edward S. Friedman, University of Pittsburgh
  • Alan J. Gelenberg, University of Arizona
  • Peter Holland, Florida Atlantic University
  • James H. Kocsis, Weill Cornell Medical College
  • Susan G. Kornstein, Virginia Commonwealth University
  • Richard C. Shelton, Vanderbilt University
  • Madhukar H. Trivedi, University of Texas
  • John M. Zajecka, Rush University
  • Corey Goldstein, Rush University
  • Michael E. Thase, University of Pennsylvania
  • Ronald D. Pedersen, Wyeth Research
  • Martin B. Keller, Brown University
UMMS Affiliation
Department of Psychiatry
Publication Date
9-16-2009
Document Type
Article
Disciplines
Abstract
Background: Antidepressant tachyphylaxis describes the return of apathetic depressive symptoms, such as fatigue and decreased motivation, despite continued use of a previously effective treatment. Methods: Data were collected from a multiphase, doubleblind, placebo-controlled study that assessed the efficacy of venlafaxine extended release (ER) during 2 sequential 1-year maintenance phases (A and B) in patients with recurrent major depressive disorder (MDD). The primary outcome was the cumulative probability of tachyphylaxis in patients receiving venlafaxine ER, fluoxetine, or placebo. Tachyphylaxis was defined as Rothschild Scale for Antidepressant Tachyphylaxis (RSAT) score Results: The maintenance phase A population was comprised of 337 patients (venlafaxine ER [n = 129], fluoxetine [n = 79], placebo [n = 129]), whereas 128 patients (venlafaxine ER [n = 43], fluoxetine [n = 45], placebo [n = 40]) were treated during maintenance phase B. No difference in the probability of experiencing tachyphylaxis were observed between the active treatment groups during either maintenance phase; however, a significant difference between venlafaxine ER and placebo was observed at the completion of maintenance phase A. A significant relationship between tachyphylaxis and recurrence was observed. Limitations: Despite demonstrating psychometric validity and reliability, the current definition of tachyphylaxis has not been widely studied. Conclusions: Although no significant differences were observed in the probability of tachyphylaxis among patients receiving active treatment, the relationship between tachyphylaxis and recurrence suggests that tachyphylaxis may be a prodrome of recurrence.
Source
Psychopharmacol Bull. 2009;42(3):5-20.
Related Resources
Link to Article in PubMed
PubMed ID
19752838
Citation Information
Anthony J. Rothschild, Boadie W. Dunlop, David L. Dunner, Edward S. Friedman, et al.. "Assessing Rates and Predictors of Tachyphylaxis During the Prevention of Recurrent Episodes of Depression With Venlafaxine ER for Two Years (PREVENT) Study" Vol. 42 Iss. 3 (2009) ISSN: 0048-5764 (Linking)
Available at: http://works.bepress.com/anthony_rothschild/10/