We assessed the influence of hormonal (oral, injectable, or levonorgestrel [Norplant, Wyeth-Ayerst, Philadelphia, PA]) and barrier methods of contraception on the risk of cervical squamous intraepithelial lesions (SIL), while adjusting for high-risk (HR) HPV infection. Subjects were women receiving family planning services through the state health department clinics from 1995 to 1998. We selected 60 cases with high-grade cervical/SIL (HSIL) and 316 with low-grade cervical/SIL (LSIL) and controls (427 women with normal cervical cytology) and analyzed cervical DNA for HR-HPV, using Hybrid Capture I (Digene; Gaithersburg, MD).When assessing ever use, duration, recency, latency, and age at first use, neither oral contraceptives (OC), Norplant, nor injectable use was associated with an increased risk of SIL development after adjusting for age, age at first sexual intercourse, and HR-HPV positivity. Among HR-HPV-positive women, longer duration barrier method use was associated with a reduced risk of SIL. This finding has important clinical implications for SIL prevention among HR-HPV-infected women.
Available at: http://works.bepress.com/anncoker/83/
Published in Journal of Women's Health & Gender-Based Medicine, v. 10, no. 5, p. 441-449.
This is a copy of an article published in the Journal of Women's Health & Gender-Based Medicine © 2001 Mary Ann Liebert, Inc.; Journal of Women's Health & Gender-Based Medicine is available online at: http://online.liebertpub.com/loi/jwh.1
Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.