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Article
Development and refinement of a technique for short-term intravascular auricular vein catheter placement in mature sows
Laboratory Animals
  • Monique D. Pairis-Garcia, Iowa State University
  • Anna Johnson, Iowa State University
  • Jessica L. Bates, Iowa State University
  • Matthew L. Stock, Iowa State University
  • L. A. Barth, Iowa State University
  • Alyssa Sue Brommel, Iowa State University
  • Kenneth J Stalder, Iowa State University
  • Locke A. Karriker, Iowa State University
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
1-1-2014
DOI
10.1177/0023677213514044
Abstract
Intravenous drug administration in adult swine is difficult to perform due to inaccessible superficial veins and thick subcutaneous fat layers. However, successful intravenous drug administration is critical for many biomedical applications including pharmacokinetic studies as extravascular drug administration can influence the drug’s absorption and elimination rate. The purpose of this study was to develop and refine an effective technique for indwelling auricular vein catheter placement in the conscious mature sow. We developed a protocol using a topical anesthetic cream and minimal physical restraint to place indwelling catheters in the auricular vein of six multiparous sows. This method was quick (3 min 20 s ± 8 s [mean ± SE per catheter]), effective (11/12 catheters successfully placed) and reliable, allowing a large drug volume (20–22 mL) to be administrated successfully during the trial without relying on prolonged restraint or general anesthesia of the sow.
Comments

This is a manuscript of an article in Laboratory Animals 48 (2014): 78, doi:10.1177/0023677213514044. Posted with permission.

Copyright Owner
MD Pairis-Garcia, et al
Language
en
File Format
application/pdf
Citation Information
Monique D. Pairis-Garcia, Anna Johnson, Jessica L. Bates, Matthew L. Stock, et al.. "Development and refinement of a technique for short-term intravascular auricular vein catheter placement in mature sows" Laboratory Animals Vol. 48 Iss. 1 (2014) p. 78 - 81
Available at: http://works.bepress.com/anna_butters-johnson/70/