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Article
Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration
BMC Veterinary Research
  • Monique D. Pairis-Garcia, Iowa State University
  • Locke A. Karriker, Iowa State University
  • Anna K. Johnson, Iowa State University
  • Butch Kukanich, Kansas State University
  • Larry W. Wulf, Iowa State University
  • Suzanne Mary Sander, Iowa State University
  • Suzanne T. Millman, Iowa State University
  • Kenneth J Stalder, Iowa State University
  • Johann F. Coetzee, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-2013
DOI
10.1186/1746-6148-9-165
Abstract
The purpose of this study was to determine intravenous (IV), intramuscular (IM) and oral (PO) FM PK in mature swine. Appropriate pain management for lameness in swine is a critical control point for veterinarians and producers, but science-based guidance on optimal housing, management and treatment of lameness is deficient. Six mature swine (121–168 kg) were administered an IV, IM, or PO dose of flunixin meglumine at a target dose of 2.2 mg/kg in a cross-over design with a 10 day washout period between treatments. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis. No adverse effects were observed with flunixin meglumine administration for all routes. Flunixin meglumine was administered at an actual mean dose of 2.21 mg/kg (range: 2.05-2.48 mg/kg) IV, IM and PO. A mean peak plasma concentration (CMAX) for IM and PO administration was 3748 ng/ml (range: 2749–6004 ng/ml) and 946 ng/ml (range: 554–1593 ng/ml), respectively. TMAX was recorded at 1.00 hour (range: 0.50-2.00 hours) and 0.61 hours (range: 0.17-2.00 hours) after PO and IM administration. Half-life (T ½ λz) for IV, IM and PO administration was 6.29 hours (range: 4.84-8.34 hours), 7.49 hours (range: 5.55-12.98 hours) and 7.08 hours (range: 5.29-9.15 hours) respectively. In comparison, bioavailability (F) for PO administration was 22% (range: 11-44%) compared to IM F at 76% (range: 54-92%). The results of the present study suggest that FM oral administration is not the most effective administration route for mature swine when compared to IV and IM. Lower F and Cmax of PO-FM in comparison to IM-FM suggest that PO-FM is less likely to be an effective therapeutic administration route.
Comments

This article is from BMC Veterinary Research 9 (2013): 165, doi:10.1186/1746-6148-9-165. Posted with permission.

Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright Owner
Monique D. Pairis-Garcia, et al.
Language
en
File Format
application/pdf
Citation Information
Monique D. Pairis-Garcia, Locke A. Karriker, Anna K. Johnson, Butch Kukanich, et al.. "Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration" BMC Veterinary Research Vol. 9 (2013) p. 1 - 7
Available at: http://works.bepress.com/anna_butters-johnson/50/