Utilizing an ethnographic case-study approach, this article examines the experiences of women of color encountering globalization, and the shifting political and economic landscape through forms of transnational organizing. Central to this analysis is an examination of the increased pressures born by women of color and the emergence of new strategies of resistance that move outside nationalist and state-centered models. The article highlights such alliances between a group of US Chicanas and Latinas from Colorado, and indigenous women in Chiapas, Mexico, paying particular attention to the transformative relationships as well as the points of tension and disruption. Overall, the article brings into conversation theories of oppositional consciousness among US ‘Third World Feminists’ and postcolonial feminist critiques of globalization to map the boundaries of a transnational feminism useful for women encountering hierarchies of race, class and gender in the new millennium.