Article
emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex
Genetics
(2011)
Abstract
In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.
Publication Date
July, 2011
DOI
10.1534/genetics.111.131714
Citation Information
Diane C Shakes, Anna K Allen, Kelsey M Albert and Andy Golden. "emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex" Genetics Vol. 189 Iss. 2 (2011) p. 549 - 560 Available at: http://works.bepress.com/anna-k-allen/2/