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Article
Modeling of EBV Infection and Antibody Responses in Kenyan Infants With Different Levels of Malaria Exposure Shows Maternal Antibody Decay is a Major Determinant of Early EBV Infection
University of Massachusetts Medical School Faculty Publications
  • Arnold Reynaldi, Kirby Institute for Infection and Immunity
  • Timothy E. Schlub, Sydney University
  • Erwan Piriou, Médecins Sans Frontières
  • Sidney Ogolla, Kenya Medical Research Institute
  • Odada P. Sumba, Kenya Medical Research Institute
  • Ann M. Moormann, University of Massachusetts Medical School
  • Rosemary Rochford, University of Colorado Denver
  • Miles P. Davenport, Kirby Institute for Infection and Immunity
UMMS Affiliation
Program in Molecular Medicine
Publication Date
11-1-2016
Document Type
Article
Abstract
The combination of Epstein-Barr virus (EBV) infection and high malaria exposure are risk factors for endemic Burkitt lymphoma, and evidence suggests that infants in regions of high malaria exposure have earlier EBV infection and increased EBV reactivation. In this study we analyzed the longitudinal antibody response to EBV in Kenyan infants with different levels of malaria exposure. We found that high malaria exposure was associated with a faster decline of maternally derived immunoglobulin G antibody to both the EBV viral capsid antigen and EBV nuclear antigen, followed by a more rapid rise in antibody response to EBV antigens in children from the high-malaria-transmission region. We also observed the long-term persistence of anti-viral capsid antigen immunoglobulin M responses in children from the high-malaria region. More rapid decay of maternal antibodies was a major predictor of EBV infection outcome, because decay predicted time to EBV DNA detection, independent of high or low malaria exposure.
Keywords
  • Burkitt Lymphoma,
  • Epstein-Barr virus,
  • P. falciparum malaria,
  • antibody,
  • immunity
DOI of Published Version
10.1093/infdis/jiw396
Source
J Infect Dis. 2016 Nov 1;214(9):1390-1398. Epub 2016 Aug 28. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
27571902
Citation Information
Arnold Reynaldi, Timothy E. Schlub, Erwan Piriou, Sidney Ogolla, et al.. "Modeling of EBV Infection and Antibody Responses in Kenyan Infants With Different Levels of Malaria Exposure Shows Maternal Antibody Decay is a Major Determinant of Early EBV Infection" Vol. 214 Iss. 9 (2016) ISSN: 0022-1899 (Linking)
Available at: http://works.bepress.com/ann_moormann/66/