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Article
Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children
University of Massachusetts Medical School Faculty Publications
  • Arnold Reynaldi, University of New South Wales
  • Timothy E. Schlub, Sydney School of Public Health
  • Kiprotich Chelimo, Kenya Medical Research Institute
  • Peter Odada Sumba, Kenya Medical Research Institute
  • Erwan Piriou, SUNY Upstate Medical University
  • Sidney Ogolla, Kenya Medical Research Institute
  • Ann M. Moormann, University of Massachusetts Medical School
  • Rosemary A. Rochford, SUNY Upstate Medical University
  • Miles P. Davenport, University of New South Wales
UMMS Affiliation
Program in Molecular Medicine
Publication Date
3-15-2016
Document Type
Article
Abstract
Endemic Burkitt lymphoma is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfection, although how P. falciparum exposure affects the dynamics of EBV infection is unclear. We have used a modeling approach to study EBV infection kinetics in a longitudinal cohort of children living in regions of high and low malaria transmission in Kenya. Residence in an area of high malaria transmission was associated with a higher rate of EBV expansion during primary EBV infection in infants and during subsequent episodes of EBV DNA detection, as well as with longer episodes of EBV DNA detection and shorter intervals between subsequent episodes of EBV DNA detection. In addition, we found that concurrent P. falciparum parasitemia also increases the likelihood of the first and subsequent peaks of EBV in peripheral blood. This suggests that P. falciparum infection is associated with increased EBV growth and contributes to endemic Burkitt lymphoma pathogenesis.
Keywords
  • Burkitt lymphoma,
  • Epstein-Barr virus,
  • P. falciparum malaria,
  • chronic infection,
  • co-infection,
  • infection dynamics
DOI of Published Version
10.1093/infdis/jiv525
Source
J Infect Dis. 2016 Mar 15;213(6):985-91. doi: 10.1093/infdis/jiv525. Epub 2015 Nov 3. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
26531246
Citation Information
Arnold Reynaldi, Timothy E. Schlub, Kiprotich Chelimo, Peter Odada Sumba, et al.. "Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children" Vol. 213 Iss. 6 (2016) ISSN: 0022-1899 (Linking)
Available at: http://works.bepress.com/ann_moormann/58/