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Density-dependent blood stage Plasmodium falciparum suppresses malaria super-infection in a malaria holoendemic population
Immunology/Infectious Disease
  • Mykola Pinkevych, University of New South Wales
  • Janka Petravic, University of New South Wales
  • Kiprotich Chelimo, Kenya Medical Research Institute
  • John M. Vulule, Kenya Medical Research Institute
  • James W. Kazura, Case Western Reserve University
  • Ann M. Moormann, University of Massachusetts Medical School
  • Miles P. Davenport, University of New South Wales
UMMS Affiliation
Department of Pediatrics
Publication Date
Document Type
Animals; Cell Count; Child; Child, Preschool; *Endemic Diseases; Erythrocytes; Humans; Infant; Infant, Newborn; Kenya; Life Cycle Stages; Liver; Malaria, Falciparum; *Models, Statistical; Plasmodium falciparum; Population Dynamics
Recent studies of Plasmodium berghei malaria in mice show that high blood-stage parasitemia levels inhibit the development of subsequent liver-stage infections. Whether a similar inhibitory effect on liver-stage Plasmodium falciparum by blood-stage infection occurs in humans is unknown. We have analyzed data from a treatment-time-to-infection cohort of children < 10 years of age residing in a malaria holoendemic area of Kenya where people experience a new blood-stage infection approximately every 2 weeks. We hypothesized that if high parasitemia blocked the liver stage, then high levels of parasitemia should be followed by a "skipped" peak of parasitemia. Statistical analysis of "natural infection" field data and stochastic simulation of infection dynamics show that the data are consistent with high P. falciparum parasitemia inhibiting liver-stage parasite development in humans.
DOI of Published Version
Am J Trop Med Hyg. 2013 Nov;89(5):850-6. doi: 10.4269/ajtmh.13-0049. Epub 2013 Sep 9. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Mykola Pinkevych, Janka Petravic, Kiprotich Chelimo, John M. Vulule, et al.. "Density-dependent blood stage Plasmodium falciparum suppresses malaria super-infection in a malaria holoendemic population" Vol. 89 Iss. 5 (2013) ISSN: 0002-9637 (Linking)
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