Skip to main content
Article
Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children
Quantitative Health Sciences Publications and Presentations
  • Chandy C. John, University of Minnesota Medical School
  • Aaron J. Tande, University of Minnesota Medical School
  • Ann M. Moormann, University of Massachusetts Medical School
  • Peter Odada Sumba, Kenya Medical Research Institute
  • David E. Lanar, Walter Reed Army Institute of Research
  • Xinan M. Min, University of Minnesota Medical School
  • James W. Kazura, Case Western Reserve University
UMMS Affiliation
Department of Quantitative Health Sciences; Department of Pediatrics
Date
2-16-2008
Document Type
Article
Medical Subject Headings
Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Cross-Sectional Studies; Endemic Diseases; Humans; Immunoglobulin G; Incidence; Infant; Kenya; Longitudinal Studies; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Protozoan Proteins; Sporozoites
Abstract
BACKGROUND: IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria. METHODS: Levels of IgG antibodies to circumsporozoite protein (CSP), liver-stage antigen type 1 (LSA-1), and thrombospondin-related adhesive protein (TRAP) were measured in 86 children in a malaria-holoendemic area of Kenya. The children were then monitored for episodes of clinical malaria for 52 weeks. RESULTS: Children with high levels of IgG antibodies to CSP, LSA-1, and TRAP had a decreased risk of clinical malaria (adjusted hazard ratio, 0.29; 95% confidence interval 0.10-0.81; P = .02), a lower incidence of clinical malaria (P=.006), protection from clinical malaria with a parasite level of > or =4000 parasites/microL (P= .03), and a higher hemoglobin level at enrollment (P= .009), compared with children with lower antibody levels. Protection against malaria morbidity was associated primarily with antibodies to CSP and LSA-1. CONCLUSIONS: Kenyan children with high levels of IgG antibodies to the pre-erythrocytic antigens CSP, LSA-1, and TRAP have a lower risk of developing clinical malaria than children without high levels of these antibodies. The decreased risk of clinical malaria may be mediated in part by prevention of high-density parasitemia.
Rights and Permissions
© 2008 by the Infectious Diseases Society of America. Citation: J Infect Dis. 2008 Feb 15;197(4):519-26. Link to article on publisher's site
Related Resources
Link to Article in PubMed
Citation Information
Chandy C. John, Aaron J. Tande, Ann M. Moormann, Peter Odada Sumba, et al.. "Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children" Vol. 197 Iss. 4 (2008) ISSN: 0022-1899 (Linking)
Available at: http://works.bepress.com/ann_moormann/30/