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Article
Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
Quantitative Health Sciences Publications and Presentations
  • Amolo S. Asito, Kenyatta University
  • Ann M. Moormann, University of Massachusetts Medical School
  • Kiprotich Chelimo, Kenya Medical Research Institute
  • Zipporah W. Ng'ang'a, Kenyatta University
  • Robert Ploutz-Snyder, SUNY Upstate Medical University
  • Rosemary A. Rochford, SUNY Upstate Medical University
UMMS Affiliation
Department of Quantitative Health Sciences; Department of Pediatrics
Date
11-21-2008
Document Type
Article
Medical Subject Headings
Animals; Antigens, CD19; Antigens, CD38; B-Lymphocytes; Case-Control Studies; Child, Preschool; Flow Cytometry; Humans; Immunoglobulin D; Immunologic Memory; Lymphocyte Subsets; Malaria, Falciparum; Neprilysin; Plasmodium falciparum
Abstract
BACKGROUND: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. RESULTS: There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset. CONCLUSION: Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
Rights and Permissions
Citation: Malar J. 2008 Nov 18;7:238. Link to article on publisher's site
Related Resources
Link to Article in PubMed
Citation Information
Amolo S. Asito, Ann M. Moormann, Kiprotich Chelimo, Zipporah W. Ng'ang'a, et al.. "Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children" Vol. 7 (2008) ISSN: 1475-2875 (Linking)
Available at: http://works.bepress.com/ann_moormann/12/