This paper investigates on motion synchronization of a multiple axes system. Two different control strategies, a cross-coupling controller in feedback loop and a linear quadratic optimal controller, were used to synthesize the synchronization compensator with the cross-coupling dynamics among the axes. These two methods are corresponding to SISO and MIMO approaches. With the strategies, the asymptotic convergence of both tracking and synchronization errors can be achieved. Simulation and experimental results of a three-axis motion system illustrate the effectiveness of the proposed approach.