This study investigated the influence of information literacy skills on the utilization of information resources by public health workers in Federal Neuro-Psychiatric Hospital, Calabar. Three research questions and hypotheses were formulated to guide the study. Survey research design was adopted for the study and purposive sampling technique was utilized to select subjects for the study. Ninety five out of the one hundred and twenty five copies of the questionnaire administered were retrieved and found treatable. A well-structured and validated questionnaire named information literacy skill and utilization of information resources (ILSUIR) questionnaire was used to collect information from the respondents. Cronbach’s Alpha reliability method was used to determine the reliability of research instrument, and coefficients of 0.74 to 0.89 were arrived at. These were considered high enough to justify the conclusion that the instrument is reliable in measuring the variables set for the study. Data obtained were subjected to statistical analyses using Independent t-test which was carried out at .05 level of significance. The result revealed that Access point, ICT competence and information evaluation significantly influenced utilization of information resources by public health workers in Federal NeuroPsychiatric Hospital, Calabar. Based on the findings it was recommended that library literacy skill programs should be organized by the authorities in the study area in order to update the staff and other users of the library on access point. It was equally recommended that the use of information and communication technology (ICT) should be encouraged while evaluation of information resource toward effective library utilization should be carried out periodically.