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Article
Association of functionally different RUNX2 P2 promoter alleles with BMD
Journal of Bone and Mineral Research (2006)
  • James D Doecke, Griffith University
  • Christopher J Day, Griffith University
  • Alexandre SJ Stephens, Griffith University
  • Shea L Carter, Queensland University of Technology
  • Angela van Daal, Queensland University of Technology
  • Mark A Kotowicz, University of Melbourne
  • Geoff C Nicholson, University of Melbourne
  • Nigel A Morrison, Griffith University
Abstract

RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD. Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2 promoter SNPs were functionally different in gel-shift and promoter activity assays.

Keywords
  • BMD,
  • RUNX2,
  • DNA sequencing,
  • cell-specific
Publication Date
February 1, 2006
Citation Information
James D Doecke, Christopher J Day, Alexandre SJ Stephens, Shea L Carter, et al.. "Association of functionally different RUNX2 P2 promoter alleles with BMD" Journal of Bone and Mineral Research (2006)
Available at: http://works.bepress.com/angela_v_daal/12/