Immigrants in the United States experience considerable stress as they attempt to integrate into the educational, social, or employment settings of the receiving society. Particularly, immigrants who have features which make them distinct from the receiving society are likely to experience increase risks of ethnic prejudice and discrimination leading to considerable stress. This study examined whether participation in a 6-day spiritual retreat results in changes in perceived stress among 88 Nigerian Catholic immigrant sisters in a mixed methods embedded design. Results show that the mean changes in perceived stress across the three-time points were statistically significant (Friedman ANOVA χ2 = 68.55; p <.0005). Mean differences indicate that perceived stress scores gradually declined, from 6.35 pre-retreat to 4.05 on day 3, and to 2.31 post-retreat. Perceived stressors reported include work exhaustion, outside discrimination, and community life. Prayer, meditation, regular self-reflection was mentioned as the most helpful spiritual activities when dealing with life stress.