Limited studies exist about how negative life events (NLEs) influence spirituality, particularly that of the Nigerian Catholic sisters living in the United States. Twenty sisters were interviewed. Content analysis of transcripts generated four themes. The themes followed a specific pattern of dealing with an adverse life situation, beginning with 1) the basic instant internal reactions to the stressor. 2) Movement from self-absorption toward an expanded view of life through reframing the NLE using spiritual approaches. 3) Outcomes of the process. This research highlights the need for spirituality to be integrated into clinical practice to improve the mental health of individuals.