This study explored the 2020 COVID-19 pandemic impact, with its unprecedented isolation norm and social distancing requirements, on African immigrants in the United States. We focused on the sources of meaning in their daily lives, how they navigated their meaning-making process, and cultural proclivities amidst the official and unofficial mandates for social distancing. Additionally, we investigated the role technologies play in the entire process. A qualitative inquiry conducted virtually generated data from a sample of 20 participants. Results show that African immigrants derive meaning from social relationships, personal life goals, religious faith, service, and good health. The COVID-19 pandemic undoubtedly threatened participants’ core meaning sources, which they rely on for life satisfaction, personal growth, and healing. Various emergent technologies helped in ameliorating the situation by providing conduits for participants to engage, albeit virtually, in most activities that positively impact their lives. This study highlights clinicians’ need to integrate meaning in life discussions in their African immigrant patients’ care and incorporate congruent technologies as needed.