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Cell Free DNA as a Marker of Training Status in Weightlifters
Biology of Sport
  • Jeremy A. Gentles, Armstrong State University
  • William G. Hornsby, West Virginia University
  • Christine L. Coniglio, Armstrong State University
  • Andy R. Dotterweich, East Tennessee State University
  • Jon A. Miller, East Tennessee State University
  • Charles A. Stuart, East Tennessee State University
  • Michael H. Stone, East Tennessee State University
Document Type
Article
Publication Date
1-1-2017
Description

The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities. The relationship between cell free DNA (cf-DNA), C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testosterone-cortisol ratio (T:C), body mass and body composition were also examined. Eight weightlifters (5 males and 3 females, age = 25 ± 3.5 yr, body mass = 88.3 ± 22.7 kg, height = 173.8 ±8.4 cm) volunteered to participate in this study. Venous blood samples, body mass and body composition were taken six times, each corresponding to the end of a training phase. CK (p = 0.018, η² = 0.409) and CK %Δ (p < 0.001, η² = 0.594) were the only biochemical variables to reach statistical significance at any point. A number of statistically significant correlations were found among variables. VLD4wk was related to CK %Δ (r = 0.86), VLD4wk %Δ was related CK %Δ (r = 0.86) and TID1wk was related to CRP (r = 0.83). cf-DNA %Δ was correlated with CRP and CRP %Δ (r = 0.83 and 0.86, respectively). CRP and CRP %Δ were correlated with BF % (r = 0.94 and 0.92, respectively). CK and CK %Δ were both related to T:C (r = 0.94 and 0.89, respectively) and T:C %Δ (r = 0.87 and 0.86, respectively). The correlation between cf-DNA and CRP suggests that cf-DNA may be a valuable indicator of inflammation in weightlifters.

Copyright Statement

Copyright: Institute of Sport. This document was originally published in Biology of Sport.

Creative Commons License
Creative Commons Attribution 4.0
Citation Information
Jeremy A. Gentles, William G. Hornsby, Christine L. Coniglio, Andy R. Dotterweich, et al.. "Cell Free DNA as a Marker of Training Status in Weightlifters" Biology of Sport Vol. 34 Iss. 3 (2017) p. 287 - 294 ISSN: 2083-1862
Available at: http://works.bepress.com/andy-dotterweich/15/