Communication and collaboration are vital aspects of 21st century librarianship, particularly for librarians in branch and regional settings who are often separated from their system colleagues by both physical distance and administrative structures. For this study, the authors conducted an exploratory survey to examine collaboration, communication, and networking behaviors and perceptions among librarians in multi-campus academic library systems. Results of this investigative study will lead to better understanding of these issues within the profession, suggest possible approaches and solutions for better models of communication and collaboration, and lay the groundwork for future research on these topics.