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Presentation
pH-Sensitive liposomes with new trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome membrane
241st American Chemical Society (ACS) National Meeting & Exposition
  • Nataliya M. Samoshina, University of the Pacific
  • Xin Liu, University of the Pacific
  • Yu Zheng, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Xin Guo, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Conference Presentation
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
Anaheim, CA
Conference Dates
March 27-31, 2011
Date of Presentation
3-28-2011
Disciplines
Abstract

We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: a protonation-induced conformational switch of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Here we report our latest studies on the pH-sensitivity of PEG-grafted liposomes containing various trans-2-aminocyclohexanol-based lipids in their membranes. These liposomes are stable at pH 7.4 and yet release their content in a few seconds in a slightly acidic medium. The triggering pH value depends on the structure of amino-group.

Citation Information
Nataliya M. Samoshina, Xin Liu, Yu Zheng, Andreas H. Franz, et al.. "pH-Sensitive liposomes with new trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome membrane" 241st American Chemical Society (ACS) National Meeting & Exposition (2011)
Available at: http://works.bepress.com/andreas-franz/89/