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Presentation
pH-Sensitive, Ortho Ester-Based Cationic Lipoplexes for Gene Delivery
3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008)
  • Xin Guo, University of the Pacific
  • H. Chen
  • Andreas H. Franz, University of the Pacific
  • H. Zhang
  • Francis C. Szoka
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Poster
Department
Chemistry
Location
Moscow, Russia
Conference Dates
June 24-28, 2008
Date of Presentation
6-24-2008
Disciplines
Abstract

We report our recent findings on pH-sensitive, ortho ester-based cationic lipids and their lipoplexes for gene delivery. At higher pH, such lipids were relatively stable and readily condensed with plasmid DNA into cationic lipoplexes. At lowered pH, such lipids rapidly hydrolysed, which in turn triggered their lipoplexes to destabilize the endosome membrane.

Citation Information
Xin Guo, H. Chen, Andreas H. Franz, H. Zhang, et al.. "pH-Sensitive, Ortho Ester-Based Cationic Lipoplexes for Gene Delivery" 3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008) (2008)
Available at: http://works.bepress.com/andreas-franz/86/