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Presentation
Thio-β-D-glucosides: Synthesis and evaluation as glycosidase inhibitors and activators
248th American Chemical Society (ACS) National Meeting
  • Nataliya M. Samoshina, University of the Pacific
  • Andrey V. Samoshin, University of the Pacific
  • Irina A. Dotsenko, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Poster
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Francisco, CA
Conference Dates
August 10-14, 2014
Date of Presentation
8-11-2014
Disciplines
Abstract
Novel structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors towards several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while the same compounds produced a weak to moderate activation of α- and β-galactosidases.
Citation Information
Nataliya M. Samoshina, Andrey V. Samoshin, Irina A. Dotsenko, Andreas H. Franz, et al.. "Thio-β-D-glucosides: Synthesis and evaluation as glycosidase inhibitors and activators" 248th American Chemical Society (ACS) National Meeting (2014)
Available at: http://works.bepress.com/andreas-franz/78/