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Non-covalent calixarene–amino acid complexes formed by MALDI-MS
Journal of the American Society for Mass Spectrometry
  • Michele M. Stone, University of California, Davis
  • Andreas H. Franz, University of California, Davis
  • Carlito B. Lebrilla, University of California, Davis
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Non-covalent inclusion complexes formed between amino acids and derivatized calix[6]arenes are observed in MALDI mass spectrometry. The methyl, ethyl, and propyl ester derivatives of calix[6]arene yielded amino acid complexes, while the smaller calix[4]arene analogs did not. Similarly the underivatized calix[6]arene and calix[4]arene did not produce complexes. Amino acid complexes were observed for nearly all 20 amino acids in time-of-flight (TOF) analysis. In Fourier transform mass spectrometry (FTMS) analysis, however, only the most basic amino acids arginine, histidine, and lysine formed stable adducts. The complexes were abundant under matrix-assisted laser desorption ionization (MALDI) conditions, which suggested favorable interactions between host and guest.
Citation Information
Michele M. Stone, Andreas H. Franz and Carlito B. Lebrilla. "Non-covalent calixarene–amino acid complexes formed by MALDI-MS" Journal of the American Society for Mass Spectrometry Vol. 13 Iss. 8 (2002) p. 964 - 974 ISSN: 1044-0305
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