NMR investigation of phospholipid/PEG-ceramide-liposomes241st American Chemical Society (ACS) National Meeting & Exposition
Document TypeConference Presentation
OrganizationAmerican Chemical Society (ACS)
Conference DatesMarch 27-31, 2011
Date of Presentation3-28-2011
AbstractLiposomes are macromolecular structures in which an aqueous core is surrounded by a double-layered lipid membrane. Surface modifications in liposomes serve the purpose of enhanced water-solubility, immuno-compatibility, and targeted delivery of liposome “cargo”, e.g. drugs or DNA/RNA. Liposomal drug delivery systems are frequently composed of phospho-lipids and ceramides amongst others. We investigated pH-sensitive liposomes. Complete NMR structure assignment and quantification of all components provided quality control. During liposome extrusion/preparation/loading and cleanup, little to no variation in composition was observed.
Citation InformationAndreas H. Franz, Nataliya M. Samoshina, Xin Guo and Vyacheslav V. Samoshin. "NMR investigation of phospholipid/PEG-ceramide-liposomes" 241st American Chemical Society (ACS) National Meeting & Exposition (2011)
Available at: http://works.bepress.com/andreas-franz/22/