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Presentation
Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations
243rd American Chemical Society (ACS) National Meeting & Exposition
  • Nataliya M. Samoshina, University of the Pacific
  • Xin Liu, University of the Pacific
  • Yu Zheng, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Xin Guo, University of the Pacific
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Poster
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Diego, CA
Conference Dates
March 25-March 29, 2012
Date of Presentation
3-28-2012
Disciplines
Abstract

We suggested recently a novel type of pH-sensitive delivery system, 'fliposomes', which contain trans-2-aminocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake in HeLa and B16F1 cells of the methotrexate-loaded fliposomes, which indicate that the latter can serve as viable drug delivery systems.

Citation Information
Nataliya M. Samoshina, Xin Liu, Yu Zheng, Andreas H. Franz, et al.. "Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations" 243rd American Chemical Society (ACS) National Meeting & Exposition (2012)
Available at: http://works.bepress.com/andreas-franz/111/