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Presentation
Design of biocompatible pH-sensitive liposomes for drug and gene delivery
239th American Chemical Society (ACS) National Meeting
  • Xin Guo, University of the Pacific
  • Nataliya M. Samoshina, University of the Pacific
  • Haigang Chen
  • Babora Brazdova, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • Huizhen Zhang
  • Francis C. Szoka
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Conference Presentation
Department
Chemistry
Organization
American Chemical Society (ACS)
Location
San Francisco, CA
Conference Dates
March 21-25, 2010
Date of Presentation
3-24-2010
Disciplines
Abstract

Since the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails.

Citation Information
Xin Guo, Nataliya M. Samoshina, Haigang Chen, Babora Brazdova, et al.. "Design of biocompatible pH-sensitive liposomes for drug and gene delivery" 239th American Chemical Society (ACS) National Meeting (2010)
Available at: http://works.bepress.com/andreas-franz/109/