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Presentation
Design of Biocompatible pH-Sensitive Liposomes for Drug and Gene Delivery
3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008)
  • Xin Guo, University of the Pacific
  • H. Chen
  • Barbora Brazdova, University of the Pacific
  • Andreas H. Franz, University of the Pacific
  • H. Zhang
  • N. Zhang
  • Francis C. Szoka
  • Vyacheslav V. Samoshin, University of the Pacific
Document Type
Poster
Department
Chemistry
Location
Moscow, Russia
Conference Dates
June 24-28, 2008
Date of Presentation
6-26-2008
Disciplines
Abstract

Since the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails.

Citation Information
Xin Guo, H. Chen, Barbora Brazdova, Andreas H. Franz, et al.. "Design of Biocompatible pH-Sensitive Liposomes for Drug and Gene Delivery" 3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008) (2008)
Available at: http://works.bepress.com/andreas-franz/104/