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Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates
Fertility and sterility
  • J. D. Kresowik
  • B. J. Stegmann
  • Amy E.T. Sparks, University of Iowa
  • Ginny L. Ryan, University of Iowa
  • Bradley J. Van Voorhis, University of Iowa
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Fertil Steril
PubMed ID
DOI of Published Version
OBJECTIVE: To report the outcomes of a program policy instituted in 2004 mandating single-embryo transfer (mSET) for all women aged <38 >years, with at least seven zygotes, no prior failed fresh cycle at our center, and at least one good-quality blastocyst. DESIGN: Retrospective cohort study. SETTING: Academic medical center. PATIENT(S): All women 1, 1999, to May 31, 2004 (before mSET) and from June 1, 2004, to May 31, 2009 (after mSET). INTERVENTION(S): mSET policy implementation. MAIN OUTCOME MEASURE(S): Live-birth rate, multiple pregnancy rate, clinical volume, and outcomes of all mSET fresh IVF transfers were analyzed. RESULT(S): Clinical volume was unchanged between the two time groups. After implementation of mSET, live-birth rates improved from 51.1% to 55.9% and multiple-birth rates dropped from 34.8% to 17.5%. A total of 364 mSET fresh transfers were performed with a live-birth rate of 64.6% and a multiple-birth rate of 3.4%. CONCLUSION(S): A mandatory SET policy based on prognostic factors can be instituted with no drop in clinical volume and no negative effect on delivery rates. Multiple gestation rates can be dramatically lowered.
  • Adult,
  • Down-Regulation,
  • Female,
  • Fertilization in Vitro/legislation & jurisprudence,
  • Guideline Adherence,
  • Health Plan Implementation,
  • Humans,
  • Mandatory Programs/legislation & jurisprudence,
  • Pregnancy,
  • Pregnancy Rate/trends,
  • Pregnancy,
  • Multiple/statistics & numerical data,
  • Single Embryo Transfer/statistics & numerical data/utilization,
  • Time Factors,
  • Twins/statistics & numerical data
Published Article/Book Citation

Fertility and sterility, 96:6 (2011) pp.1367-1369.

Citation Information
J. D. Kresowik, B. J. Stegmann, Amy E.T. Sparks, Ginny L. Ryan, et al.. "Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates" Fertility and sterility Vol. 96 Iss. 6 (2011) p. 1367 - 1369 ISSN: 1556-5653
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