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'Old' bones in young bodies: the tale of cystic fibrosis
Current opinion in endocrinology, diabetes, and obesity
  • Amy E.T. Sparks, University of Iowa
  • S. J. McGee
  • C. E. Boone
  • I. P. Neuringer
  • S. K. Jones
  • R. M. Aris
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Curr Opin Endocrinol Diabetes Obes
PubMed ID
DOI of Published Version
PURPOSE OF REVIEW: Cystic fibrosis (CF) is the most common genetic disease within the white population and leads to premature respiratory failure. Approximately, 60 000 individuals are currently living with CF in North America and Europe, almost half of whom are adults. RECENT FINDINGS: Dozens of studies across the globe indicate that CF adults have low bone density and increased rates of fractures. This genesis of the problem appears to be in late childhood to adolescence. SUMMARY: Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased serum levels of proinflammatory, bone-active cytokines, malnutrition and low body weight, physical inactivity and glucocorticoid therapy) for poor bone health. This review will address the pathogenesis, diagnosis and treatment of bone disease in CF. It will also discuss best practice guidelines for optimizing bone health in patients with CF.
  • Adult,
  • Bone Density,
  • Bone Diseases,
  • Endocrine/diagnosis/etiology/therapy,
  • Cystic Fibrosis/complications/physiopathology,
  • Fractures,
  • Bone/etiology,
  • Humans,
  • Practice Guidelines as Topic,
  • Young Adult
Published Article/Book Citation
Current opinion in endocrinology, diabetes, and obesity, 16:6 (2009) pp.407-414.
Citation Information
Amy E.T. Sparks, S. J. McGee, C. E. Boone, I. P. Neuringer, et al.. "'Old' bones in young bodies: the tale of cystic fibrosis" Current opinion in endocrinology, diabetes, and obesity Vol. 16 Iss. 6 (2009) p. 407 - 414 ISSN: 1752-2978
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