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Article
Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele
Fertility and sterility
  • B. C. Stahl
  • S. R. Patil
  • Craig H. Syrop, University of Iowa
  • Amy E.T. Sparks, University of Iowa
  • M. Wald
Document Type
Article
Peer Reviewed
1
Publication Date
5-1-2007
NLM Title Abbreviation
Fertil Steril
PubMed ID
17208235
DOI of Published Version
10.1016/j.fertnstert.2006.09.008
Abstract
OBJECTIVE: To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. DESIGN: Case report. SETTING: Urologic infertility clinic in a university hospital. PATIENT(S): Male patient presenting with primary infertility. INTERVENTION(S): Karyotyping, genetic counseling, and microsurgical left varicocelectomy. MAIN OUTCOME MEASURE(S): Sperm concentration and motility, chromosomal number and structure. RESULT(S): Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. CONCLUSION(S): A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients.
Keywords
  • Adult,
  • Chromosomes,
  • Human,
  • Pair 14,
  • Humans,
  • Infertility,
  • Male/diagnosis/genetics/surgery,
  • Male,
  • Ring Chromosomes,
  • Varicocele/diagnosis/genetics/surgery
Published Article/Book Citation
Fertility and sterility, 87:5 (2007) pp.1213.e1-1213.e3.
Citation Information
B. C. Stahl, S. R. Patil, Craig H. Syrop, Amy E.T. Sparks, et al.. "Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele" Fertility and sterility Vol. 87 Iss. 5 (2007) p. 12130 - 1213000 ISSN: 1556-5653
Available at: http://works.bepress.com/amy_sparks/24/