Blenderized formula by gastrostomy tube (BFGT) has been suggested as a substrate in children who have demonstrated intolerance to traditional formula feeding. Alleviation of gagging, retching, constipation, diarrhea, and food refusal in gastrostomy-fed children is reported in the literature when all or part of the tube feeding is replaced with pureed foods. The paucity of evidence-based research on BFGT should not preclude its consideration in clinical practice. Optimal BFGT outcomes are noted when patients meet selection criteria and oversight is provided by a registered dietitian. BFGT represents a potential area of medical nutrition therapy research and underscores the importance of multidisciplinary collaboration of the feeding team to improve outcomes in pediatric populations.