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Predictors and Characteristics of Response and Nonresponse: A Ten Year Follow-Up of First Episode Schizophrenia in Mumbai
Psychiatry Presentations
  • Amresh Shrivastava, University of Western Ontario
  • Nilesh Shah, University of Mumbai
  • Megan Johnston, University of Toronto
  • Larry Stitt, University of Western Ontario
  • Meghana Thakar, Silver Mind Hospital, Mumbai, India
  • Gurusamy Chinnasamy, Northern Alberta Institute of Technology
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▪ It is not clearly known what predicts good long-term outcome in first episode schizophrenia and what the characteristics are that differentiate patients who do and do not show good response

▪ We attempted to find the characteristics and predictors of good out-come for patients who presented with severe psychopathology and were hospitalized in their first episode psychosis in a tertiary psychiatric hospital in the city of Mumbai

▪ 101 patients of first episode schizophrenia were assessed at hospitalization, and reassessed at ten years

▪ The data was analyzed on 13 outcome parameters for predictors and characteristics of good outcome, using the SAS system of statistical analysis

▪ 61 of 101 patients showed good outcome on the CGIS after ten years

▪ Predictors of good recovery were high baseline positive symptoms and low negative symptoms, higher anxiety-depressive symptoms, lower level of depressive symptoms, lower level of aggression, higher work performance and ability to live independently.

▪ Characteristics of non-recovered patients showed higher extra pyramidal symptoms, severe aggressive symptoms, higher frequency of disorganization symptoms at baseline and higher level of family burden at the end of the term

▪ Our study shows reasonably good outcome [61.7%] in first episode-hospitalized patients

▪ Good outcome correlated with severity of positive symptoms, level of work function and ability to live independently at baseline

A poster presentation at the Annual National Conference of the Indian Psychiatry Society in Jaipur, India in Jan. 2010
Citation Information
Amresh Shrivastava, Nilesh Shah, Megan Johnston, Larry Stitt, et al.. "Predictors and Characteristics of Response and Nonresponse: A Ten Year Follow-Up of First Episode Schizophrenia in Mumbai" (2010)
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