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Article
Eye Suppression, A Novel Function of Teashirt, Requires Wingless Signaling
Development
  • Amit Singh, University of Dayton
  • Madhuri Kango-Singh, University of Dayton
  • Y. Henry Sun, Academia Sinica
Document Type
Article
Publication Date
9-1-2002
Abstract
Teashirt (tsh) encodes a Drosophila zinc-finger protein. Misexpression of tsh has been shown to induce ectopic eye formation in the antenna. We report that tsh can suppress eye development. This novel function of tsh is due to the induction of homothorax (hth), a known repressor of eye development, and requires Wingless (WG) signaling. Interestingly, tsh has different functions in the dorsal and ventral eye, suppressing eye development close to the ventral margin, while promoting eye development near the dorsal margin. It affects both growth of eye disc and retinal cell differentiation.
Inclusive pages
4271-4280
ISBN/ISSN
0950-1991
Document Version
Published Version
Comments

This document is provided for download in compliance with the publisher's policy on self-archiving. Permission documentation is on file.

Publisher
Company of Biologists
Peer Reviewed
Yes
Citation Information
Amit Singh, Madhuri Kango-Singh and Y. Henry Sun. "Eye Suppression, A Novel Function of Teashirt, Requires Wingless Signaling" Development Vol. 129 Iss. 18 (2002)
Available at: http://works.bepress.com/amit_singh/43/