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A Glimpse into Dorso-Ventral Patterning of the Drosophila Eye
Developmental Dynamics
  • Amit Singh, University of Dayton
  • Meghana Tare, University of Dayton
  • Oorvashi Roy Puli, University of Dayton
  • Madhuri Kango-Singh, University of Dayton
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During organogenesis in all multi-cellular organisms, axial patterning is required to transform a single layer organ primordium into a three-dimensional organ. The Drosophila eye model serves as an excellent model to study axial patterning. Dorso-ventral (DV) axis determination is the first lineage restriction event during axial patterning of the Drosophila eye. The early Drosophila eye primordium has a default ventral fate, and the dorsal eye fate is established by onset of dorsal selector gene pannier (pnr) expression in a group of cells on the dorsal eye margin. The boundary between dorsal and ventral compartments called the equator is the site for Notch (N) activation, which triggers cell proliferation and differentiation. This review will focus on (1) chronology of events during DV axis determination; (2) how early division of eye into dorsal and ventral compartments contributes towards the growth and patterning of the fly retina; and (3) functions of DV patterning genes.

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Wiley Periodicals
Peer Reviewed
Citation Information
Amit Singh, Meghana Tare, Oorvashi Roy Puli and Madhuri Kango-Singh. "A Glimpse into Dorso-Ventral Patterning of the Drosophila Eye" Developmental Dynamics Vol. 241 Iss. 1 (2012)
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