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Article
Eyeless Collaborates with Hedgehog and Decapentaplegic Signaling in Drosophila Eye Induction
Developmental Biology
  • Madhuri Kango-Singh, University of Dayton
  • Amit Singh, University of Dayton
  • Y. Henry Sun, Academia Sinica
Document Type
Article
Publication Date
4-1-2003
Abstract
eyeless (ey) is a key regulator of the eye development pathway in Drosophila. Ectopic expression of ey can induce the expression of several eye-specification genes (eya, so,and dac) and induce eye formation in multiple locations on the body. However, ey does not induce eye formation everywhere where it is ectopically expressed, suggesting that EY needs to collaborate with additional factors for eye induction. We examined ectopic eye induction by EY in the wing disc and found that eye induction was spatially restricted to the posterior compartment and the anterior–posterior (A/P) compartmental border, suggesting a requirement for both HH and DPP signaling. Although EY in the anterior compartment induced dpp and dac, these were not sufficient for eye induction. Coexpression experiments show that EY needs to collaborate with high level of HH and DPP to induce ectopic eye formation. Ectopic eye formation also requires the activation of an eye-specific enhancer of the endogenous hh gene.
Inclusive pages
49–61
ISBN/ISSN
0012-1606
Comments

Permission documentation is on file.

Publisher
Elsevier
Peer Reviewed
Yes
Citation Information
Madhuri Kango-Singh, Amit Singh and Y. Henry Sun. "Eyeless Collaborates with Hedgehog and Decapentaplegic Signaling in Drosophila Eye Induction" Developmental Biology Vol. 256 Iss. 1 (2003)
Available at: http://works.bepress.com/amit_singh/24/