Visionaries and scientists from the early days of computing and electronic communication have discussed the proper role of technology to improve human experience. Technology now plays an increasingly important role in facilitating and improving personal and social activities and engagements, decision making, interaction with physical and social worlds, generating insights, and just about anything that a human, as an intelligent being, seeks to do. This article presents a vision of Physical-Cyber-Social (PCS) computing for a holistic treatment of data, information, and knowledge from physical, cyber, and social worlds to integrate, understand, correlate, and provide contextually relevant abstractions to humans.