This mixed-methods research study shows that the incorporation of real-time polling in an introductory Anthropology course (n = 107) taught in a large lecture class at a mid-size university can have a positive impact on students' perceptions of (1) satisfaction; (2) participation; and (3) whether the instructor was able to use the polling results effectively to gauge students' understanding. Independent sample t-test and ANOVA results indicated gender, race, and extroversion level were shown to have significant impacts on participation and understanding. Students did not show a significant preference for either of the two real-time polling systems (TopHat or TurningPoint) used in this study. This study shows how the incorporation of real-time polling in large, introductory, lecture classes can have a positive impact on students and has the potential to decrease the attrition rates and to improve student learning enrolled in these classes.