Presentation
Assessing the association between serum β-carotene, body mass index, and markers of inflammation in United States adults
Nutrition 2018
(2018)
Abstract
Objectives: Worldwide obesity rates are high, therefore understanding the health consequences and mortality risk associated with obesity is important. The relationships between obesity, low-grade inflammation, and oxidative stress is well established in longitudinal studies. However, how serum carotenoid concentrations correlate with obesity-related inflammation in population samples is not well understood. Our primary objective is to test the hypothesis that serum β-carotene concentrations are independently associated with body mass index (BMI) and the inflammatory marker high-sensitivity C-reactive protein (hsCRP), utilizing datasets from the National Health and Nutrition Examination Surveys (NHANES).
Methods: Data from 9,349 male and non-pregnant female participants 20-85 years in the NHANES 2003-2006 nationally representative, cross-sectional survey were analyzed to estimate the relationships among BMI, hsCRP, and serum β-carotene. Due to skewing, we log transformed serum β-carotene and hsCRP. Multiple linear regression estimated log(serum β-carotene) based on BMI and log(hsCRP) adjusted for age, sex, and ethnicity.
Results: Prevalence of low serum β-carotene concentrations (<50 μg/dL) was 86.7%, and prevalence of obesity was 32.6%. Mean and standard deviation (SD) was 2.51±0.85 for log(β-carotene)and -1.65±1.31 for log(hsCRP). Mean and SD for BMI was 28.27±6.55. log(Serum β-carotene) was inversely associated with BMI (r= -0.19, p<0.0001) and log(hsCRP) (r=-0.16, p<0.0001), and the correlation of BMI with log(hsCRP) was r=0.44 (P<0.0001). Mean untransformed serum β-carotene was significantly lower in obese subjects compared to normal weight subjects (14.39 ± 14.87 versus 21.80 ± 24.46 μg/dL, p<0.001). The log of serum β-carotene concentration was lower by 0.13±0.01 μg/dL for each SD higher BMI and lower by 0.18±0.01 μg/dL for each SD higher log(hsCRP), which are respectively 15 and 21% of the SD of log(serum β-carotene).
Conclusions: Substantial associations were found among serum β-carotene concentrations and BMI and hsCRP. These factors may contribute to the increased risk of chronic disease, particularly in obese individuals.
Keywords
- Nutritional Epidemiology
Disciplines
Publication Date
June, 2018
Location
Boston, MA
Citation Information
Ambria Crusan. "Assessing the association between serum β-carotene, body mass index, and markers of inflammation in United States adults" Nutrition 2018 (2018) Available at: http://works.bepress.com/ambria-crusan/2/