A systematic review was conducted to produce an up-to-date and comprehensive summary of qualitative and quantitative evidence specific to the factors related to undergraduate Latina/o student academic success outcomes during college. Findings indicate that a combination of (a) socio-cultural characteristics, (b) academic self-confidence, (c) beliefs, ethnic/racial identity, and coping styles, (d) pre-college academic experiences, (e) college experiences, (f) internal motivation and commitment, (g) interactions with supportive individuals, (h) perceptions of the campus climate/environment, and (i) institutional type/characteristics are related to one or more academic success outcomes for Latina/o students.