Since states began implementing the Workforce Investment Act (WIA) of 1998, One-Stop Career Centers have had to address the challenges of serving all customers seeking services, including job seekers with disabilities. To meet this challenge, many local One-Stops have demonstrated commitment to and progress towards creating innovative practices that positively affect access for job seekers with disabilities in the workforce system. The following brief is offered as a tool for local workforce systems to help achieve meaningful employment outcomes for job seekers with disabilities. This brief is part of a series of products offering practical solutions for Local Workforce Investment Boards and One-Stop Career Centers as they strive to serve all customers, including those with disabilities. Topics covered in other briefs include fiscal issues, creative involvement of community-based disability organizations, and partnerships with Vocational Rehabilitation (VR). The source of the information presented below is from case studies conducted in Los Angeles, California; Colorado Springs, Colorado; Wilmington, Delaware; New Orleans, Louisiana; Utica, New York; and Clark County, Washington. These case studies were conducted by researchers at the Institute for Community Inclusion at University of Massachusetts Boston.