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Article
Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence
Graduate School of Medicine - Papers (Archive)
  • Tharaka L Dassanayake, University of Newcastle
  • Patricia Michie, University of Newcastle
  • Gregory Carter, University of Newcastle
  • Alison L Jones, University of Western Sydney
RIS ID
62114
Publication Date
1-1-2010
Publication Details

Dassanayake, T. L., Michie, P., Carter, G. Jones, A. L. (2010). Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence. Drug Safety, 34 (2), 125-156.

Abstract

Background: Many individuals in the community are prescribed psychoactive drugs with sedative effects. These drugs may affect their daily functions, of which automobile driving is a major component. Objective: To examine the association of three classes of commonly used psychoactive drugs (viz. benzodiazepines and newer non-benzodiazepine hypnotics, antidepressants and opioids) with (i) the risk of traffic accidents (as indexed by epidemiological indicators of risk); and (ii) driving performance (as indexed by experimental measures of driving performance). Methods: A literature search for material published in the English language between January 1966 and January 2010 in PubMed and EMBASE databases was combined with a search for other relevant material referenced in the retrieved articles. Retrieved articles were systematically reviewed, carrying out meta-analyses where possible. Twenty-one epidemiological studies (13 case-control and 8 cohort studies) fulfilled the inclusion criteria by estimating the accident risk associated with drug exposure (ascertained by blood/urine analysis or prescription records). Sixty-nine experimental studies fulfilled the inclusion criteria by testing actual or simulated driving performance after administering a single dose or multiple doses.

Citation Information
Tharaka L Dassanayake, Patricia Michie, Gregory Carter and Alison L Jones. "Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence" (2010) p. 125 - 156
Available at: http://works.bepress.com/alison_jones/28/