Associate Professor of Bioengineering
Areas of Interest: cell mechanics; cell-biomaterial interactions; and tissue engineering.
In the body, tissues can be thought of as being made up of cells, a fluid phase, and the solid extracellular matrix that gives the tissue its form. Cells within a tissue can both generate and receive signals from molecules within their surrounding fluid as well as from the solid matrix support that they interact with. While the chemical signals provided by soluble molecules have been extensively studied, our understanding of the chemical and mechanical signals provided by the extracellular matrix has only begun to be elucidated. Dr. Sieminski investigates the impact changing the mechanical environment that cells sense, in combination with changing the biochemical environment, on cell behavior. The primary tool in this work is a three-dimensional model system of angiogenesis - the formation of new blood vessels. Understanding the effects of material properties, and how the stimulus they provide combine with other stimulus to direct cell behavior, has implications for not only fundamental cell biology, but also for cancer and the design of new biomaterials.
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In the body, tissues can be thought of as being made up of cells, a fluid phase, and the solid extracellular matrix that gives the tissue its form. Cells within a tissue can both generate and receive signals from molecules within their surrounding fluid as well as from the solid matrix support that they interact with. While the chemical signals provided by soluble molecules have been extensively studied, our understanding of the chemical and mechanical signals provided by the extracellular matrix has only begun to be elucidated. Dr. Sieminski investigates the impact changing the mechanical environment that cells sense, in combination with changing the biochemical environment, on cell behavior. The primary tool in this work is a three-dimensional model system of angiogenesis - the formation of new blood vessels. Understanding the effects of material properties, and how the stimulus they provide combine with other stimulus to direct cell behavior, has implications for not only fundamental cell biology, but also for cancer and the design of new biomaterials.
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About Alisha L. Sarang-Sieminski
Areas of Interest: cell mechanics; cell-biomaterial interactions; and tissue engineering.
In the body, tissues can be thought of as being made up of cells, a fluid phase, and the solid extracellular matrix that gives the tissue its form. Cells within a tissue can both generate and receive signals from molecules within their surrounding fluid as well as from the solid matrix support that they interact with. While the chemical signals provided by soluble molecules have been extensively studied, our understanding of the chemical and mechanical signals provided by the extracellular matrix has only begun to be elucidated. Dr. Sieminski investigates the impact changing the mechanical environment that cells sense, in combination with changing the biochemical environment, on cell behavior. The primary tool in this work is a three-dimensional model system of angiogenesis - the formation of new blood vessels. Understanding the effects of material properties, and how the stimulus they provide combine with other stimulus to direct cell behavior, has implications for not only fundamental cell biology, but also for cancer and the design of new biomaterials.
In the body, tissues can be thought of as being made up of cells, a fluid phase, and the solid extracellular matrix that gives the tissue its form. Cells within a tissue can both generate and receive signals from molecules within their surrounding fluid as well as from the solid matrix support that they interact with. While the chemical signals provided by soluble molecules have been extensively studied, our understanding of the chemical and mechanical signals provided by the extracellular matrix has only begun to be elucidated. Dr. Sieminski investigates the impact changing the mechanical environment that cells sense, in combination with changing the biochemical environment, on cell behavior. The primary tool in this work is a three-dimensional model system of angiogenesis - the formation of new blood vessels. Understanding the effects of material properties, and how the stimulus they provide combine with other stimulus to direct cell behavior, has implications for not only fundamental cell biology, but also for cancer and the design of new biomaterials.
| Present | Associate Professor of Bioengineering, Olin College of Engineering | |
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Disciplines
Research Interests
Courses
- Topics in Bioengineering
- Tissue Engineering
- Transport in Biological Systems
- Cellular Bioengineering
Contact Information
http://faculty.olin.edu/~asieminski/index.html
Email: