SelectedWorks - Alicia R. Timme-Laragy

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Selected Works of Alicia R. Timme-Laragy

Associate Professor, Department of Environmental Health Sciences, School of Public Health & Health Sciences

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About Alicia R. Timme-Laragy

Present	Assistant Professor, Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts Amherst
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Public Health and Environmental Health and Protection

149C Goessmann Laboratory
University of Massachusetts Amherst
686 North Pleasant Street
Amherst, MA 01003
Tel: 413-545-7423

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Mapping glutathione utilization in the development zerbrafish (Danio rerio) embryo

Redox Biology (2019)

Archit Rastogi, Christopher W. Clark, Sarah E. Brown and Alicia R. Timme-Laragy

Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH ...

Embryonic Exposure to Mono(2-ethylhexyl) Phthalate (MEHP) Disrupts Pancreatic Organogenesis ...

Chemosphere (2018)

Haydee M. Jacobs, Karilyn E. Sant, Aviraj Basnet, Larissa M. Williams, et al.

Mono(2-ethylhexyl) phthalate (MEHP) is the bioactive metabolite of di(2-ethylhexyl) phthalate, a plasticizing agent and persistent environmental contaminant associated with obesity, ...

Nrf2a Modulates the Embryonic Antioxidant Response to Perfluorooctanesulfonic Acid (PFOS ...

Aquatic Toxicology (2018)

Karilyn E. Sant, Paul P. Sinno, Haydee M. Jacobs and Alicia R. Timme-Laragy

The glutathione redox system undergoes precise and dynamic changes during embryonic development, protecting against and mitigating oxidative insults. The antioxidant ...

Pancreatic beta cells are a sensitive target of embryonic exposure ...

Birth Defects Research (2018)

Sarah E. Brown, Karilyn E. Sant, Shana M. Fleischman, Olivia L. Venezia, et al.

BACKGROUNDButylparaben (butyl p-hydroxybenzoic acid) is a common cosmetic and pharmaceutical preservative reported to induce oxidative stress and endocrine disruption. Embryonic ...

Perfluorobutanesulfonic Acid (PFBS) Potentiates Adipogenesis of 3T3-L1 Adipocytes

Food and Chemical Toxicology (2018)

Weipeng Qi, John M. Clark, Alicia R. Timme-Laragy and Yeonhwa Park

Perfluorobutanesulfonic acid (PFBS) is used as the replacement of perfluorooctanesulfonic acid (PFOS) since 2000 because of the concern on PFOS’ ...

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism ...

Toxicological Sciences (2018)

Karilyn E. Sant, Olivia L. Venezia, Paul P. Sinno and Alicia R. Timme-Laragy

Following the phase-out of highly persistent perfluorosulfonates in the United States from non-stick and stain-resistant products in the early 2000s, ...

Redox stress and signaling during vertebrate embryonic development: regulation and ...

Seminars in Cell & Developmental Biology (2018)

Alicia R. Timme-Laragy, Mark E. Hahn, Jason M. Hansen, Archit Rastogi, et al.

Vertebrate embryonic development requires specific signaling events that regulate cell proliferation and differentiation to occur at the correct place and ...

Zebrafish as a Model for Toxicological Perturbation of Yolk and ...

Current Environmental Health Reports (2018)

Karilyn E. Sant and Alicia R. Timme-Laragy

Purpose of ReviewDevelopmental toxicity assessments often focus on structural outcomes and overlook subtle metabolic differences which occur during the early ...

The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects ...

PLOS ONE (2014)

Mark E. Hahn, Andrew G. McArthur, Sibel I. Karchner, Diana G. Franks, et al.

Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis and to cardiovascular and neurodegenerative diseases. Developing animals ...

Glutathione Redox Dynamics and Expression of Glutathione-related Genes in the ...

Free Radical Biology and Medicine (2013)

Alicia R. Timme-Laragy, Jared V. Goldstone, Barry R. Imhoff, John J. Stegemana, et al.

Embryonic development involves dramatic changes in cell proliferation and differentiation that must be highly coordinated and tightly regulated. Cellular redox ...

Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family ...

PLOS ONE (2013)

Larissa M. Williams, Alicia R. Timme-Laragy, Jared V. Goldstone, Andrew G. McArthur, et al.

Transcription factors in the CNC-bZIP family (NFE2, NRF1, NRF2 and NRF3) regulate genes with a wide range of functions in ...

Differential Sensitivity to Pro-Oxidant Exposure in Two Populations of Killifish ...

Ecotoxicology (2013)

Rachel C. Harbeitner, Mark E. Hahn and Alicia R. Timme-Laragy

New Bedford Harbor (MA, U.S.A.; NBH) is a Superfund site inhabited by Atlantic killifish (Fundulus heteroclitus) with altered aryl hydrocarbon ...

Common Commercial and Consumer Products Contain Activators of the Aryl ...

PLOS ONE (2013)

Bin Zhao, Jessica E. S. Bohonowych, Alicia R. Timme-Laragy, Dawoon Jung, et al.

Activation of the Ah receptor (AhR) by halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD, dioxin), can produce a wide ...

Ahr2-Dependance of PCB126 Effects on the Swimbladder in Relation to ...

Toxicolology and Applied Pharmacology (2012)

Maria E. Jönsson, Akira Kubota, Alicia R. Timme-Laragy, Bruce Woodin, et al.

The teleost swimbladder is assumed a homolog of the tetrapod lung. Both swimbladder and lung are developmental targets of persistent ...

Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs ...

Toxicological Sciences (2009)

Alicia R. Timme-Laragy, Lindsey A. Van Tiem, Elwood A. Linney and Richard T. Di Giulio

Early piscine life stages are sensitive to polycyclic aromatic hydrocarbon (PAH) exposure, which can cause pericardial effusion and craniofacial malformations. ...

Fluoranthene, but Not Benzo[a]pyrene, Interacts with Hypoxia Resulting ...

Chemosphere (2008)

Cole W. Matson, Alicia R. Timme-Laragy and Richard T Di Giulio

Previous research has documented several PAHs that interact synergistically, causing severe teratogenicity in developing fish embryos. The coexposure of CYP1A ...

CYP1B1 Knockdown Does Not Alter Synergistic Developmental Toxicity of Polycyclic ...

Marine Environmental Research (2008)

Alicia R. Timme-Laragy, Pamela D. Noyes, Donald R. Buhler and Richard T. Di Giulio

Polycyclic aromatic hydrocarbons (PAHs) are contaminants increasing in the environment largely due to burning of fossil fuels. Our previous work ...

Newspapers and Newspaper Ink Contain Agonists for the Ah Receptor

Toxicological Sciences (2008)

Jessica E. S. Bohonowych, Bin Zhao, Alicia R. Timme-Laragy, Dawoon Jung, et al.

Ligand-dependent activation of the aryl hydrocarbon receptor (AhR) pathway leads to a diverse array of biological and toxicological effects. The ...

Synergistic Induction of AHR Regulated Genes in Developmental Toxicity from ...

Aquatic Toxicology (2007)

Alicia R. Timme-Laragy, Crystal J. Cockman, Cole W. Matson and Richard T. Di Giulio

Polycyclic aromatic hydrocarbons (PAHs) are pollutants created by the incomplete combustion of carbon, and are increasing in the environment largely ...