Other
Plasminogen Activator inhibitor (PAI-1) activity as a biomarker and target for therapeutic intervention.
(2019)
Abstract
Pleural loculation or scarring in the pleural space is now difficult to treat and is associated with poor outcomes. As a member of a research team at UTHSCT, we identified PAI-1 activity as a biomarker and target for therapeutic intervention. Our ultimate goal is to identify a novel PAI-1-targeted intrapleural fibrinolytic therapeutic, which we will advance to IND-enabling work in anticipation of near-term clinical trial testing to provide better, safer treatment for patients with pleural loculation.
Disciplines
Publication Date
2019
Citation Information
Ali Azghani. "Plasminogen Activator inhibitor (PAI-1) activity as a biomarker and target for therapeutic intervention." (2019) Available at: http://works.bepress.com/ali-azghani/99/