Other
Cellular Mechanism of Pulmonary edema
(2019)
Abstract
Pseudomonas aeruginosa frequently infects patients with cystic fibrosis and immunocompromised individuals. One of the first steps in pulmonary injury is the loss of epithelium integrity; which is followed by inflammation and edema. Previous reports from our lab indicate that P. aeruginosa elastase (PE) activates host cells’ signal transduction pathways that, in part, contribute to tight junction disruption. The exact mechanism of epithelial disruption, however, is not yet fully understood. We investigate the role of cell receptors and signaling cascades in PE-induced modification of Tight Junction organization and epithelial barrier integrity. An in vitro model of human pulmonary epithelial cell (Calu-3) grown on tissue culture inserts are utilized in this project.
Disciplines
Publication Date
2019
Citation Information
Ali Azghani. "Cellular Mechanism of Pulmonary edema" (2019) Available at: http://works.bepress.com/ali-azghani/98/