Other
Liposomal antibiotics in Infection Therapy
(2019)
Abstract
Liposomes are emerging as a preferred drug carrier to combat antibiotic resistant strains due to their ability to fuse with the prokaryotic cell membrane as the endpoint of their carrier function. In this project, we investigate the efficacy of this alternate method on microbial adhesion, which is accepted as a prerequisite to P. aeruginosa colonization and infection. Using A549 pulmonary epithelial cells, we quantify P. aeruginosa adhesions to host cells using fluorescence microscopy and colony forming unit assay. Theultimate goal is to safely eliminate bacterial infections caused by organism resistant to conventional drugs. Our hypothesis for this line of research is that the use of liposomal antibiotics as opposed to conventional methods will augment the existing antibiotics ability to efficiently inhibit the adherence of P. aeruginosa to human lung cells and therefore decrease susceptibility to infection.
Disciplines
Publication Date
2019
Citation Information
Ali Azghani. "Liposomal antibiotics in Infection Therapy" (2019) Available at: http://works.bepress.com/ali-azghani/96/