We studied the effect of Kerr nonlinearity on lasing in defect modes of weakly disordered photonic crystals. Our time-independent calculation based on self-consistent nonlinear transfer matrix method shows that Kerr nonlinearity modifies both frequencies and quality factors of defect modes. We also used a time-dependent algorithm to investigate the dynamic nonlinear effect. Under continuous pumping, the spatial sizes and intensities of defect lasing modes are changed by Kerr nonlinearity. Such changes are sensitive to the nonlinear response time.