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Article
Two clinical isolates of Mycoplasma hyosynoviae showed differing pattern of lameness and pathogen detection in experimentally challenged pigs
Faculty Publications in Food Science and Technology
  • João Carlos Gomes-Neto, Iowa State University
  • Matthew Raymond, Iowa State University
  • Leslie Bower, Iowa State University
  • Alejandro Ramirez, Iowa State University
  • Darin M. Madson, Iowa State University
  • Erin L. Strait, Iowa State University
  • Everett L. Rosey, Zoetis Inc.
  • Vicki J. Rapp-Gabrielson, Zoetis Inc.
Date of this Version
1-1-2016
Disciplines
Citation

J Vet Sci 2016, 17(4), 489-496

Comments

ⓒ 2016 The Korean Society of Veterinary Science.

Abstract
Mycoplasma (M.) hyosynoviae is known to colonize and cause disease in growing-finishing pigs. In this study, two clinical isolates of M. hyosynoviae were compared by inoculating cesarean-derived colostrum-deprived and specific-pathogen-free growing pigs. After intranasal or intravenous inoculation, the proportion and distribution pattern of clinical cases was compared in addition to the severity of lameness. Tonsils were found to be the primary site of colonization, while bacteremia was rarely detected prior to the observation of clinical signs. Regardless of the clinical isolate, route of inoculation, or volume of inocula, histopathological alterations and tissue invasion were detected in multiple joints, indicating an apparent lack of specific joint tropism. Acute disease was primarily observed 7 to 10 days post-inoculation. The variability in the severity of synovial microscopic lesions and pathogen detection in joint cavities suggests that the duration of joint infection may influence the diagnostic accuracy. In summary, these findings demonstrate that diagnosis of M. hyosynoviae-associated arthritis can be influenced by the clinical isolate, and provides a study platform to investigate the colonization and virulence potential of field isolates. This approach can be particularly relevant to auxiliate in surveillance and testing of therapeutic and/or vaccine candidates.
Citation Information
João Carlos Gomes-Neto, Matthew Raymond, Leslie Bower, Alejandro Ramirez, et al.. "Two clinical isolates of Mycoplasma hyosynoviae showed differing pattern of lameness and pathogen detection in experimentally challenged pigs" (2016)
Available at: http://works.bepress.com/alejandro_ramirez/36/